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Article

Prevalence of Variant Reclassification Following Hereditary Cancer Genetic Testing.

JAMA - 25 Sept 2018

Mersch Jacqueline, Brown Nichole, Pirzadeh-Miller Sara, Mundt Erin, Cox Hannah C, Brown Krystal, Aston Melissa, Esterling Lisa, Manley Susan, Ross Theodora

Abstract excerpt

Importance: Variant reclassification is an important component of hereditary cancer genetic testing; however, there are few published data quantifying the prevalence of reclassification. Objective: Retrospective cohort study of individuals who had genetic testing from 2006 through 2016 at a single commercial laboratory. Design, Setting, and Participants: A retrospective cohort of individuals who had genetic...

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Identifiers

PMID: 30264118
DOI: 10.1001/jama.2018.13152
PMCID: PMC6233618

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