Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delineating gene-environment effects using virtual twins of patients treated with clozapine.

CPT: pharmacometrics & systems pharmacology - 1 Feb 2023

Mostafa Sam, Polasek Thomas M, Bousman Chad, Rostami-Hodjegan Amin, Sheffield Leslie J, Everall Ian, Pantelis Christos, Kirkpatrick Carl M J

Abstract excerpt

Studies that focus on individual covariates, while ignoring their interactions, may not be adequate for model-informed precision dosing (MIPD) in any given patient. Genetic variations that influence protein synthesis should be studied in conjunction with environmental covariates, such as cigarette smoking. The aim of this study was to build virtual twins (VTs) of real patients receiving clozapine with interacting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Clozapine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 36424701
DOI: 10.1002/psp4.12886
PMCID: PMC9931435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delineating gene-environment effects using virtual twins of patients treated with clozapine.PMID 36424701Read ↗

Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scoresSemantic proximity Read ↗

Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia.Semantic proximity Read ↗

Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation.Semantic proximity Read ↗

Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine MetabolismSemantic proximity Read ↗

Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring dataSemantic proximity Read ↗

A Digital Twin of Glimepiride for Personalized and Stratified Diabetes TreatmentSemantic proximity Read ↗

Polygenic Liability for Antipsychotic Dosage and Polypharmacy - A Real-World Registry and Biobank StudySemantic proximity Read ↗

Classical twin design in modern pharmacogenomics studies.Semantic proximity Read ↗

Virtual brain twins guide personalized treatment decision in schizophreniaSemantic proximity Read ↗

Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: A longitudinal analysis and GWAS using clinical monitoring data from the UKSemantic proximity Read ↗

Modeling Clinical Phenotype Variability: Consideration of Genomic Variations, Computational Methods, and Quantitative Proteomics.Semantic proximity Read ↗

Clinical pharmacokinetics of antipsychotics in pediatric populations: a scoping review focusing on dosing regimen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.