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Article

Whole-exome sequencing of BRCA-negative breast cancer patients and case-control analyses identify variants associated with breast cancer susceptibility.

Human genomics - 23 Nov 2022

Lee Ning Yuan, Hum Melissa, Amali Aseervatham Anusha, Lim Wei Kiat, Wong Matthew, Myint Matthew Khine, Tay Ru Jin, Ong Pei-Yi, Samol Jens, Lim Chia Wei, Ang Peter, Tan Min-Han, Lee Soo-Chin, Lee Ann S G

Abstract excerpt

BACKGROUND: For the majority of individuals with early-onset or familial breast cancer referred for genetic testing, the genetic basis of their familial breast cancer remains unexplained. To identify novel germline variants associated with breast cancer predisposition, whole-exome sequencing (WES) was performed. METHODS: WES on 290 BRCA1/BRCA2-negative Singaporeans with early-onset breast cancer and/or a family...

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Identifiers

PMID: 36424660
DOI: 10.1186/s40246-022-00435-7
PMCID: PMC9685974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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