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Article

A Polymorphism in the TMPRSS2 Gene Increases the Risk of Death in Older Patients Hospitalized with COVID-19.

Viruses - 18 Nov 2022

de Andrade Clara Caldeira, Silva Ana Tércia Paulo, Vasconcelos Luydson Richardson Silva, Oliveira Pablo Rafael Silveira, de Souza Carlos Dornels Freire, da Costa Armstrong Anderson, do Carmo Rodrigo Feliciano

Abstract excerpt

BACKGROUND: Transmembrane serine protease type 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) are the main molecules involved in the entry of SARS-CoV-2 into host cells. Changes in TMPRSS2 expression levels caused by single nucleotide polymorphisms (SNPs) may contribute to the outcome of COVID-19. The aim was to investigate the association between TMPRSS2 gene polymorphisms and the risk of death in...

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Identifiers

PMID: 36423166
DOI: 10.3390/v14112557
PMCID: PMC9696669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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