Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strategies to enhance CAR-T persistence

23 Nov 2022

Abstract excerpt

Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute lymphoblastic leukemia (B-ALL), although the primary response rate is promising, the high incidence of early relapse has caused modest long-term survival with CAR-T cell alone. One of the main challenges is the limited persistence of CAR-T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36419115
DOI: 10.1186/s40364-022-00434-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strategies to enhance CAR-T persistencePMID 36419115Read ↗

Engineering better chimeric antigen receptor T cellsSemantic proximity Read ↗

Analysis of causes for poor persistence of CAR-T cell therapy in vivoSemantic proximity Read ↗

The progress of CAR-T therapy in cancer and beyondSemantic proximity Read ↗

CRISPR/Cas9: A Powerful Strategy to Improve CAR-T Cell PersistenceSemantic proximity Read ↗

Chimeric antigen receptor T cell persistence and memory cell formationSemantic proximity Read ↗

Overcoming the challenges of primary resistance and relapse after CAR-T cell therapySemantic proximity Read ↗

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cellsSemantic proximity Read ↗

Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumoursSemantic proximity Read ↗

CAR-T Cell TherapySemantic proximity Read ↗

Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T CellsSemantic proximity Read ↗

CAR‐T‐cell products in solid tumors: Progress, challenges, and strategiesSemantic proximity Read ↗

Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic FunctionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.