Article
Integrating bulk and single-cell sequencing reveals the phenotype-associated cell subpopulations in sepsis-induced acute lung injury.
Frontiers in immunology - 1 Jan 2022
Wang Fuquan, Chen Ming, Ma Jiamin, Wang Chenchen, Wang Jingxu, Xia Haifa, Zhang Dingyu, Yao Shanglong
Abstract excerpt
The dysfunctional immune response and multiple organ injury in sepsis is a recurrent theme impacting prognosis and mortality, while the lung is the first organ invaded by sepsis. To systematically elucidate the transcriptomic changes in the main constituent cells of sepsis-injured lung tissue, we applied single-cell RNA sequencing to the lung tissue samples from septic and control mice and created a comprehensive...
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