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Article

PVT1/miR-145-5p/HK2 modulates vascular smooth muscle cells phenotype switch via glycolysis: The new perspective on the spiral artery remodeling.

Placenta - 1 Dec 2022

Wu Mengying, Liu Weifang, Huang Haixia, Chen Zhirui, Chen Yangyang, Zhong Yanqi, Jin Zhishan, Liu Xiaoxia, Zou Li

Abstract excerpt

INTRODUCTION: Vascular smooth muscle cells (VSMC) switched from a contractile phenotype to a synthetic phenotype during the decidual spiral artery (SPAs) remodeling process. The lncRNA plasmacytoma variant translocation 1 (PVT1) and glucose metabolism have been found to regulate the VSMC phenotype switch. This study aimed to analyze the dynamic expression of PVT1 and glycolytic key enzymes hexokinase2 (HK2) at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

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Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to RNA, Long Noncoding

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Source

Identifiers

PMID: 36370492
DOI: 10.1016/j.placenta.2022.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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