Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiplexed Digital Spatial Protein Profiling Reveals Distinct Phenotypes of Mononuclear Phagocytes in Livers with Advanced Fibrosis.

Cells - 26 Oct 2022

Lee Jaejun, Kim Chang Min, Cha Jung Hoon, Park Jin Young, Yu Yun Suk, Wang Hee Jung, Sung Pil Soo, Jung Eun Sun, Bae Si Hyun

Abstract excerpt

Background and Aims: Intrahepatic mononuclear phagocytes (MPs) are critical for the initiation and progression of liver fibrosis. In this study, using multiplexed digital spatial protein profiling, we aimed to derive a unique protein signature predicting advanced liver fibrosis. Methods: Snap-frozen liver tissues from various chronic liver diseases were subjected to spatially defined protein-based multiplexed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Kupffer Cells
Share to Liver Cirrhosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 36359782
DOI: 10.3390/cells11213387
PMCID: PMC9654480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiplexed Digital Spatial Protein Profiling Reveals Distinct Phenotypes of Mononuclear Phagocytes in Livers with Advanced Fibrosis.PMID 36359782Read ↗

Multiplexed digital spatial protein profiling reveals a unique protein signature for advanced liver fibrosisSemantic proximity Read ↗

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomicsSemantic proximity Read ↗

High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver MetastasisSemantic proximity Read ↗

Single-cell and spatial transcriptomics reveals the human liver immunological landscape and myeloid dysfunction in PSCSemantic proximity Read ↗

Multi-Omics Deciphering of the Characteristics, Functional Mechanisms, and Prognostic Value of Tumor-Associated Macrophage Subsets in Hepatocellular CarcinomaSemantic proximity Read ↗

Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated <i>SPP1</i> <sup>+</sup> macrophages and fibroblastsSemantic proximity Read ↗

A Human Single-cell Atlas Identifies OLR1+ Scar-associated Macrophages as a Therapeutic Target for Chronic Liver DiseaseSemantic proximity Read ↗

Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinomaSemantic proximity Read ↗

Deep Spatial Sequencing Revealing Differential Immune Responses in Human Hepatocellular CarcinomaSemantic proximity Read ↗

Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic ReprogrammingSemantic proximity Read ↗

A Unique Immune-Related Gene Signature Represents Advanced Liver Fibrosis and Reveals Potential Therapeutic TargetsSemantic proximity Read ↗

Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.