Article
Avirulent phenotype promotes Bordetella pertussis adaptation to the intramacrophage environment.
Emerging microbes & infections - 1 Dec 2023
Farman Mariam R, Petráčková Denisa, Kumar Dilip, Držmíšek Jakub, Saha Argha, Čurnová Ivana, Čapek Jan, Hejnarová Václava, Amman Fabian, Hofacker Ivo, Večerek Branislav
Abstract excerpt
Bordetella pertussis, the causative agent of whooping cough, is an extracellular, strictly human pathogen. However, it has been shown that B. pertussis cells can escape phagocytic killing and survive in macrophages upon internalization. Our time-resolved RNA-seq data suggest that B. pertussis efficiently adapts to the intramacrophage environment and responds to host bactericidal activities. We show that this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.