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Article

Fundamental differences in physiology of Bordetella pertussis dependent on the two-component system Bvg revealed by gene essentiality studies.

Microbial genomics - 1 Dec 2020

Belcher Thomas, MacArthur Iain, King Jerry D, Langridge Gemma C, Mayho Matthew, Parkhill Julian, Preston Andrew

Abstract excerpt

The identification of genes essential for a bacterium's growth reveals much about its basic physiology under different conditions. Bordetella pertussis, the causative agent of whooping cough, adopts both virulent and avirulent states through the activity of the two-component system, Bvg. The genes essential for B. pertussis growth in vitro were defined using transposon sequencing, for different Bvg-determined...

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Source

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Identifiers

PMID: 33295860
DOI: 10.1099/mgen.0.000496
PMCID: PMC8116675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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