Article

Two mammalian-like cysteine dioxygenases and a sulfite exporter play important roles in sulfur homeostasis and virulence of a human pathogen

2026-04-23

Abstract excerpt

Bordetella pertussis is a strictly human, re-emerging respiratory pathogen and the causative agent of whooping cough. Through its adaptation to humans, B. pertussis decayed or lost genes of the sulfate assimilation pathway and, consequently, must obtain cysteine from the host. Previously, we showed that the sulfur metabolism of B. pertussis is substantially rewired during infection of human macrophages. Here, we...

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Literature Corpus work: 387b2f0f-6751-56e6-965b-19e432253fc9
DOI: 10.64898/2026.04.22.720190

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