Article
Clinicopathological and molecular characterization of KRAS wild-type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes.
The Journal of pathology - 1 Jul 2025
Toriyama Kazuhiro, Masago Katsuhiro, Shibata Noriko, Haneda Masataka, Kuwahara Takamichi, Natsume Seiji, Kobayashi Shota, Fujita Yasuko, Sasaki Eiichi, Yamao Kenji, Kawashima Hiroki, Shimizu Yasuhiro, Hara Kazuo, Yatabe Yasushi, Hosoda Waki
Abstract excerpt
Pancreatic ductal adenocarcinomas (PDACs) with wild-type KRAS constitute a small fraction of PDACs, and these tumors were recently shown to harbor frequent actionable oncogenic mutations and fusions. However, the clinicopathological features of KRAS wild-type PDAC have not been well studied. Additionally, precancerous lesions occurring in patients with KRAS wild-type PDACs have rarely been characterized. Here, we...
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