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Melanin and Neuromelanin: Linking Skin Pigmentation and Parkinson's Disease

9 Nov 2022

Abstract excerpt

Neuromelanin-containing dopaminergic neurons in the substantia nigra pars compacta (SNpc) are the most vulnerable neurons in Parkinson's disease (PD). Recent work suggests that the accumulation of oxidized dopamine and neuromelanin mediate the convergence of mitochondrial and lysosomal dysfunction in patient-derived neurons. In addition, the expression of human tyrosinase in mouse SNpc led to the formation of...

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PMID: 36350228
DOI: 10.1002/mds.29260

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