Article

Investigating shared genetic architecture between pigmentation genetics and Parkinson’s Disease

2025-05-03

Abstract excerpt

Peripheral melanin and neuromelanin share a common biosynthetic initiation. Peripheral melanin (eumelanin and pheomelanin) is cyclically produced and degraded, while neuromelanin accumulates in dopaminergic neurons over time. Neurons containing excess neuromelanin (e.g., substantia nigra) exhibit increased degeneration in Parkinson’s patients, suggesting a potential genetic interplay between pigmentation pathways...

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Literature Corpus work: eba94dc6-4d95-516d-bcca-b539ae65994f
DOI: 10.1101/2025.04.30.25326753

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