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Article

Disruption of MenT2 toxin impairs the growth of Mycobacterium tuberculosis in guinea pigs

7 Nov 2022

Abstract excerpt

Toxin–antitoxin (TA) systems are abundantly present in the genomes of various bacterial pathogens. TA systems have been implicated in either plasmid maintenance or protection against phage infection, stress adaptation or disease pathogenesis. The genome of Mycobacterium tuberculosis encodes for more than 90 TA systems and 4 of these belong to the type IV subfamily (MenAT family). The toxins and antitoxins...

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PMID: 36342835
DOI: 10.1099/mic.0.001246

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