Article
HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
Virology - 30 Sept 2006
Wherry E John, Day Cheryl L, Draenert Rika, Miller Joseph D, Kiepiela Photini, Woodberry Tonia, Brander Christian, Addo Marylyn, Klenerman Paul, Ahmed Rafi, Walker Bruce D
Abstract excerpt
Chronic infections in mice can result in defects in memory CD8 T cell properties including low expression of the IL-7Ralpha (CD127). To determine whether defects in memory CD8 T cell formation exist during human chronic infections and to what extent these defects may be allele- or epitope-specific, we compared influenza (Flu), vaccinia (VV) and EBV-specific CD8 T cells to HIV-specific CD8 T cells, using a panel...
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