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Nucleic acid direct delivery to fibroblasts: a review of nucleofection and applications

4 Nov 2022

Abstract excerpt

The fibroblast is one of the ideal target cell candidates for cell-based gene therapy approaches to promote tissue repair. Gene delivery to fibroblasts by viral transfection has been confirmed to have high transfection efficiency. However, in addition to immunogenic effects of viruses, the random integration of viral genes may damage the genome, affect the cell phenotype or even cause cancerous mutations in the...

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PMID: 36329479
DOI: 10.1186/s13036-022-00309-5

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