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Article

Genetic Effects of ITPK1 Polymorphisms on the Risk of Neural Tube Defects: a Population-Based Study.

Reproductive sciences (Thousand Oaks, Calif.) - 1 May 2023

Guan Zhen, Liang Yingchao, Zhu ZhiQiang, Yang Aiyun, Li Shen, Wang Xiuwei, Wang Jianhua

Abstract excerpt

Inositol is closely related to the occurrence of neural tube defects (NTDs). Inositol 1, 3, 4-trisphosphate 5/6-kinase (ITPK1) gene encoded an essential regulatory enzyme ITPK1, which is involved in inositol metabolism and has a critical role in the development of neural tube and axial mesoderm. It had been reported that some polymorphisms of critical genes in inositol pathways, including ITPK1, were associated...

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PMID: 36323916
DOI: 10.1007/s43032-022-01116-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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