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Novel Variants of IGF2 Gene Are Linked With Neural Tube Defects-An In Silico to Clinical Approach in West Bengal, India.

Birth defects research - 1 Jan 2025

Paul Nirvika, Sadhukhan Susanta, Chatterjee Srilagna, Das Anwesha, Munian Dinesh, Ganguly Kausik, Bankura Biswabandhu, Ghosh Krishnendu, Ghosh Sudakshina, Das Madhusudan

Abstract excerpt

BACKGROUND: Neural tube defects (NTDs) are defined as an incomplete closure of the neural tube (NT), with a prevalence of 1.2 per 1000 live births around the world. Methylation of the maternally imprinted gene Insulin-like growth factor 2 (IGF2) is one of the epigenetic mechanisms that contribute significantly to the development of NTDs. Its important functions are the fetal growth and metabolism, as well as cell...

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PMID: 39763120
DOI: 10.1002/bdr2.2428

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IGF2

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