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Article

The maternal ITPK1 gene polymorphism is associated with neural tube defects in a high-risk Chinese population.

PloS one - 1 Jan 2014

Guan Zhen, Wang Jianhua, Guo Jin, Wang Fang, Wang Xiuwei, Li Guannan, Xie Qiu, Han Xu, Niu Bo, Zhang Ting

Abstract excerpt

BACKGROUND: Epidemiological surveys and animal studies have revealed that inositol metabolism is associated with NTDs, but the mechanisms are not clear. Inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) is a pivotal regulatory enzyme in inositol metabolic pathway. The objective was to assess the potential impact of the maternal ITPK1 genotypes on the inositol parameter and on the NTD risk in a NTD high-risk area in...

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Source

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Identifiers

PMID: 24465924
DOI: 10.1371/journal.pone.0086145
PMCID: PMC3896452

Genes

ITPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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