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Article

Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway.

Acta neuropathologica communications - 17 Dec 2022

Wang Zongyi, Wang Xinliang, Shi Lingyu, Cai Yuan, Hu Bing

Abstract excerpt

Wolfram Syndrome (WS) is a fatal human inherited disease with symptoms of diabetes, vision decreasing, and neurodegeneration caused by mutations in the endoplasmic reticulum (ER)-resident protein WFS1. WFS1 has been reported to play an important role in glucose metabolism. However, the role of WFS1 in axonal regeneration in the central nervous system has so far remained elusive. Herein, we established a model of...

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Identifiers

PMID: 36527091
DOI: 10.1186/s40478-022-01484-8
PMCID: PMC9758940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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