Comprehensive overview of disease models for Wolfram syndrome: toward effective treatments.

Abstract excerpt

Wolfram syndrome (OMIM 222300) is a rare autosomal recessive disease with a devastating array of symptoms, including diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing loss, and neurological dysfunction. The discovery of the causative gene, WFS1, has propelled research on this disease. However, a comprehensive understanding of the function of WFS1 remains unknown, making the development of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Calmodulin-Binding Proteins
• Share to Membrane Proteins