The avoiding late diagnosis of ovarian cancer (ALDO) project; a pilot national surveillance programme for women with pathogenic germline variants in BRCA1 and BRCA2.

doi:10.1136/jmg-2022-108741

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The avoiding late diagnosis of ovarian cancer (ALDO) project; a pilot national surveillance programme for women with pathogenic germline variants in BRCA1 and BRCA2.

Journal of medical genetics - 1 May 2023

Philpott Sue, Raikou Maria, Manchanda Ranjit, Lockley Michelle, Singh Naveena, Scott Malcolm, Evans D Gareth, Adlard Julian, Ahmed Munaza, Edmondson Richard, Woodward Emma Roisin, Lamnisos Athena, Balega Janos, Brady Angela F, Sharma Aarti, Izatt Louise, Kulkarni Anjana, Tripathi Vishakha, Solomons Joyce S, Hayes Kevin, Hanson Helen, Snape Katie, Side Lucy, Skates Steve, McGuire Alistair, Rosenthal Adam N

Abstract excerpt

BACKGROUND: Our study aimed to establish 'real-world' performance and cost-effectiveness of ovarian cancer (OC) surveillance in women with pathogenic germline BRCA1/2 variants who defer risk-reducing bilateral salpingo-oophorectomy (RRSO). METHODS: Our study recruited 875 female BRCA1/2-heterozygotes at 13 UK centres and via an online media campaign, with 767 undergoing at least one 4-monthly surveillance test...

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PMID: 36319079
DOI: 10.1136/jmg-2022-108741
PMCID: PMC10176325

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