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The challenging screen detection of ovarian cancer in BRCA mutation carriers adhering to a 6-month follow-up program: results from a 6-years surveillance.

Menopause (New York, N.Y.) - 1 Nov 2021

Grandi Giovanni, Fiocchi Federica, Cortesi Laura, Toss Angela, Boselli Fausto, Sammarini Margaret, Sighinolfi Giovanna, Facchinetti Fabio

Abstract excerpt

OBJECTIVE: Approximately 25% of ovarian cancer (OC) cases are related to an inherited predisposition. Genetic mutations for the oncosuppressor genes BRCA1 and 2 have the best-known linkage to a higher incidence of OC and breast cancer, in approximately 70% to 80% of hereditary OC cases. To provide the first comprehensive clinical description of screen-detected (SD) OCs during a 6-years surveillance of a cohort of...

Topics

Breast Neoplasms
Female
Follow-Up Studies
Genes, BRCA2
Genetic Predisposition to Disease
Humans
Mutation
Ovarian Neoplasms
Prospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34726192
DOI: 10.1097/GME.0000000000001883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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