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Article

Uptake of Risk-Reducing Salpingo-Oophorectomy and Gynaecologic Surveillance Among Germline BRCA Pathogenic Variants Carriers.

Cancer medicine - 1 Dec 2024

Inzoli Alessandra, Negri Serena, Dell'Oro Cristina, Costa Clarissa, Marchetta Liliana, Boccadutri Mariaclara, Fumagalli Simona, Roversi Gaia, Sala Elena Maria, Celi Chiara, Rossi Valentina, Fruscio Robert

Abstract excerpt

INTRODUCTION: Risk-reducing salpingo-oophorectomy (RRSO) is recommended by international guidelines in women with BRCA1/2 germline pathogenic variants (PV) to prevent ovarian cancer. Despite the solid recommendation, women frequently refuse surgery and uptake rates reported in the literature are diverse. This study analyses the uptake rate of RRSO in BRCA 1/2 PV-carriers referred to a specialised referral centre...

Topics

Humans
Female
Salpingo-oophorectomy
Middle Aged
Ovarian Neoplasms
Prospective Studies
Germ-Line Mutation
Adult
BRCA2 Protein
BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Aged

Risk Reduction Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 39624976
DOI: 10.1002/cam4.70321
PMCID: PMC11612664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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