Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N-Cinnamamide/Benzamide-(4-(Substituted Phenyl)-6-(4-Cyclohexylphenyl)pyrimidin-2-Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT, EGFRT790M, and EGFRL858R /T790M/C797S in NSCLC.

doi:10.1111/cbdd.70390

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Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N-Cinnamamide/Benzamide-(4-(Substituted Phenyl)-6-(4-Cyclohexylphenyl)pyrimidin-2-Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT, EGFRT790M, and EGFRL858R /T790M/C797S in NSCLC.

Chemical biology & drug design - 1 Sept 2026

Pal Rohit, Matada Gurubasavaraja Swamy Purawarga, Teli Ghanshyam, Bv Manjushree, Moulishankar Anguraj, Chawla Viney, Chawla Pooja A

Abstract excerpt

Non-small cell lung cancer (NSCLC), driven by mutations in the epidermal growth factor receptor (EGFR), presents significant therapeutic challenges, particularly due to drug resistance. This study describes the design, synthesis, and evaluation of a series of novel N-Cinnamamide/benzamide-(4-(substituted phenyl)-6-(4-cyclohexylphenyl)pyrimidin-2-yl) derivatives (Ri-Rxii) as EGFR inhibitors. Among these, compound...

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Topics

Humans
ErbB Receptors
Carcinoma, Non-Small-Cell Lung
Drug Design
Protein Kinase Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Line, Tumor

Molecular Docking Simulation

Lung Neoplasms

Antineoplastic Agents

Benzamides

Cinnamates

Pyrimidines

Apoptosis

Cell Proliferation

Mutation

Tyrosine Kinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 42711921
DOI: 10.1111/cbdd.70390
PMCID: PMC13554467

Genes

EGFR

Variants

Provenance

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