Article
Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men.
Scientific reports - 31 Oct 2022
Teleka Stanley, Orho-Melander Marju, Liedberg Fredrik, Melander Olle, Jirström Karin, Stocks Tanja
Abstract excerpt
There is substantial genetic predisposition to bladder cancer (BC). Recently, blood pressure (BP) was positively associated with BC risk in men, but the potential interaction with genetic susceptibility for BC is unknown. We investigated a weighted genetic risk score (wGRS) of 18 BC genetic variants, BP, and their interaction, in relation to incident urothelial cancer (UC, n = 385) risk in 10,576 men. We used Cox...
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