Article
Association between single nucleotide polymorphism SLCO1B1 gene and simvastatin pleiotropic effects measured through flow-mediated dilation endothelial function parameters.
Therapeutic advances in cardiovascular disease - 1 Jan 2000
Andrianto, Puspitasari Mia, Ardiana Meity, Dewi Ivana Purnama, Shonafi Khubay Alvia, Kusuma Wardhani Louisa Fadjri, Nugraha Ricardo Adrian
Abstract excerpt
BACKGROUND: Atherosclerosis is a condition in which the medium to large arteries become inflamed over time. The cornerstone to the atherosclerosis process is endothelial dysfunction. Simvastatin is a cholesterol-lowering drug known for its endothelial cell pleiotropic properties. The role of genetic polymorphisms in simvastatin-resistance difficulties has recently piqued people's interest. This problem is thought...
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