Article
[Diagnostic approaches and clinical relevance of hereditary hematological malignancies].
Magyar onkologia - 21 Mar 2025
Csabán Dóra, Borsy Éva Adrienn, Varga Lívia, Tankó Lenke, Őrfi Zoltán, Bors András, Harasztdombi József, Fábián János, Várkonyi Andrea, Lakatos Viktor, Kállay Krisztián, Kriván Gergely, Gopcsa László, Reményi Péter, Andrikovics Hajnalka
Abstract excerpt
Hereditary hematological malignancies (HHM) are characterized by genetic heterogeneity, variable penetrance, and expressivity. Although individual gene involvement is rare, germline pathogenic variants are estimated to be present in at least 5-10% of hematological malignancies. In cases diagnosed at young age, with positive family history, or with multiple malignancies (including myeloid neoplasms after cytotoxic...
Read the complete abstract on PubMedTopics
- Humans
- Hematologic Neoplasms
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation