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E and prM proteins of genotype V Japanese encephalitis virus are required for its increased virulence in mice

1 Nov 2019

Abstract excerpt

We previously showed that the Japanese encephalitis virus (JEV) genotype V (GV) strain Muar exhibits significantly higher virulence in mice than the genotype I (GI) JEV strain Mie/41/2002. In this study, we attempted to identify the region responsible for the increased virulence of GV JEV using recombinant intertypic and single mutant JEVs. Intertypic viruses containing the GV E region in the Mie/41/2002 backbone...

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PMID: 31799464
DOI: 10.1016/j.heliyon.2019.e02882

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