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Article

Impact of a haplotype (composed of the APC, KRAS, and TP53 genes) on colorectal adenocarcinoma differentiation and patient prognosis.

Cancer genetics - 1 Nov 2022

Peng Xinyu, Zhang Tao, Jia Xiongjie, Wang Tong, Lin Hengxue, Li Gang, Li Riheng, Zhang Aimin

Abstract excerpt

BACKGROUND: Many types of gene mutation are associated with the drug resistance of cancer cells. XELOX is a new and efficient surgical adjuvant chemotherapy for colorectal adenocarcinoma. However, drug-resistant related genetic mutations associated with this treatment remain unknown. METHODS: Next-generation sequencing (NGS) was performed on 36 colorectal cancer patients to identify mutations among patients with...

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PMID: 36288643
DOI: 10.1016/j.cancergen.2022.10.002

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