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Article

Impact of Pharmacogenetic Markers on the Efficacy of Neoadjuvant FLOT Chemotherapy in Patients with Gastric and Gastroesophageal Junction Adenocarcinoma.

International journal of molecular sciences - 4 May 2026

Fedorinov Denis, Lyadov Vladimir, Lyadova Marina, Abdullaev Sherzod, Kachanova Anastasia, Filatova Anna, Ivashchenko Dmitriy, Sychev Dmitry

Abstract excerpt

Despite the adoption of neoadjuvant FLOT chemotherapy as standard treatment for locally advanced gastric and gastroesophageal junction cancer, many patients fail to achieve meaningful pathological response, limiting efficacy. The aim of this study was to evaluate the impact of pharmacogenetic markers on pathological response in Russian patients receiving neoadjuvant FLOT. Thirty patients with locally advanced...

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42123691
DOI: 10.3390/ijms27094114
PMCID: PMC13164360

Genes

ERCC1
CYP2C8
CYP3A5
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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