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Article

Validation of Genetic Markers Associated with Survival in Colorectal Cancer Patients Treated with Oxaliplatin-Based Chemotherapy.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2022

Park Hanla A, Seibold Petra, Edelmann Dominic, Benner Axel, Canzian Federico, Alwers Elizabeth, Jansen Lina, Schneider Martin, Hoffmeister Michael, Brenner Hermann, Chang-Claude Jenny

Abstract excerpt

BACKGROUND: Associations between candidate genetic variants and treatment outcomes of oxaliplatin, a drug commonly used for colorectal cancer patients, have been reported but not robustly established. This study aimed to validate previously reported prognostic and predictive genetic markers for oxaliplatin treatment outcomes and evaluate additional putative functional variants. METHODS: Fifty-three SNPs were...

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Identifiers

PMID: 34862210
DOI: 10.1158/1055-9965.EPI-21-0814
PMCID: PMC9789680

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