Article
Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout.
Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2023
Sumpter Nicholas A, Takei Riku, Cadzow Murray, Topless Ruth K G, Phipps-Green Amanda J, Murphy Rinki, de Zoysa Janak, Watson Huti, Qasim Muhammad, Lupi Alexa S, Abhishek Abhishek, Andrés Mariano, Crișan Tania O, Doherty Michael, Jacobsson Lennart, Janssen Matthijs, Jansen Tim L, Joosten Leo A B, Kapetanovic Meliha, Lioté Frédéric, Matsuo Hirotaka, McCarthy Geraldine M, Perez-Ruiz Fernando, Riches Philip, Richette Pascal, Roddy Edward, Stiburkova Blanka, So Alexander, Tausche Anne-Kathrin, Torres Rosa J, Uhlig Till, Major Tanya J, Stamp Lisa K, Dalbeth Nicola, Choi Hyon K, Vazquez Ana I, Leask Megan P, Reynolds Richard J, Merriman Tony R
Abstract excerpt
OBJECTIVE: To determine whether a gout polygenic risk score (PRS) is associated with age at gout onset and tophaceous disease in European, East Polynesian, and West Polynesian men and women with gout. METHODS: A 19-variant gout PRS was produced in 7 European gout cohorts (N = 4,016), 2 East Polynesian gout cohorts (N = 682), and 1 West Polynesian gout cohort (N = 490). Sex-stratified regression models were used...
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