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Multiomics study of nonalcoholic fatty liver disease

24 Oct 2022

Abstract excerpt

Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. For NAFL, we utilized 9,491 clinical cases and proton density fat fraction extracted from 36,116 liver magnetic resonance images. We identified 18 sequence variants associated with...

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PMID: 36280732
DOI: 10.1038/s41588-022-01199-5

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