Article
Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes.
Scientific data - 8 Dec 2015
Wruck Wasco, Kashofer Karl, Rehman Samrina, Daskalaki Andriani, Berg Daniela, Gralka Ewa, Jozefczuk Justyna, Drews Katharina, Pandey Vikash, Regenbrecht Christian, Wierling Christoph, Turano Paola, Korf Ulrike, Zatloukal Kurt, Lehrach Hans, Westerhoff Hans V, Adjaye James
Abstract excerpt
Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within, e.g., APOC3, PNPLA3, NCAN, TM6SF2 and PPP1R3B, correlate with NAFLD. Several studies have already investigated later stages...
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