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Article

Mitochondrial Dysfunction in Genetic Animal Models of Parkinson's Disease

17 Aug 2011

Abstract excerpt

UNLABELLED: Mitochondria are highly dynamic, multifunctional organelles. Aside from their major role in energy metabolism, they are also crucial for many cellular processes including neurotransmission, synaptic maintenance, calcium homeostasis, cell death, and neuronal survival. SIGNIFICANCE: Increasing evidence supports a role for abnormal mitochondrial function in the molecular pathophysiology of Parkinson's...

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Identifiers

PMID: 21848447
DOI: 10.1089/ars.2011.4200

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