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Article

Elevated homocysteine associated with higher cardiovascular risk in young patients with myocardial infarction: the role of metabolic phenotypes.

Frontiers in endocrinology - 1 Jan 2026

Liu Jing-Yu, Wang Yu-Hang, Li Chang-Ping, Cui Zhuang, Liu Yin, Gao Jing

Abstract excerpt

Background: Premature myocardial infarction (PMI) is increasingly recognized as a metabolic disease, driven by a cluster of dysregulations including insulin resistance and central obesity. While homocysteine (Hcy)-an intermediate of one-carbon metabolism-is implicated in these atherothrombotic processes, its synergistic effect with coexisting cardiometabolic risk factors for the long-term prognosis of PMI...

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Identifiers

PMID: 42181207
DOI: 10.3389/fendo.2026.1821132
PMCID: PMC13193844

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