Hypothyroidism has a protective causal association with hepatocellular carcinoma: A two-sample Mendelian randomization study

Abstract excerpt

Objective Observational studies suggest an association between hypothyroidism and the risk of hepatocellular carcinoma (HCC), but the causality and direction of these effects are still inconclusive. We aim to test whether hypothyroidism is causally associated with the risk of HCC by using Mendelian randomization (MR) analysis. Methods Single-nucleotide polymorphisms (SNPs) associated with hypothyroidism were...

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