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MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling

15 Oct 2022

Abstract excerpt

OBJECT: A large number of studies have suggested that stemness is an essential mechanism for drug resistance, metastasis and relapse in hepatocellular carcinoma (HCC). The aim of this study was to determine the impact of MCM2 on stemness and identify potential mechanisms that complement the stemness regulatory network in HCC. METHODS: MCM2 expression features and prognostic significance were analyzed in multiple...

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PMID: 36243809
DOI: 10.1038/s41420-022-01201-3

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