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Article

Candidate Modifier Genes for the Penetrance of Leber's Hereditary Optic Neuropathy.

International journal of molecular sciences - 6 Oct 2022

Cheng Hui-Chen, Chi Sheng-Chu, Liang Chiao-Ying, Yu Jenn-Yah, Wang An-Guor

Abstract excerpt

Leber’s hereditary optic neuropathy (LHON) is a maternally transmitted disease caused by mitochondria DNA (mtDNA) mutation. It is characterized by acute and subacute visual loss predominantly affecting young men. The mtDNA mutation is transmitted to all maternal lineages. However, only approximately 50% of men and 10% of women harboring a pathogenic mtDNA mutation develop optic neuropathy, reflecting both the...

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Source

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Identifiers

PMID: 36233195
DOI: 10.3390/ijms231911891
PMCID: PMC9569928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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