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Article

Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families.

Investigative ophthalmology & visual science - 1 Oct 2010

Qu Jia, Wang Ying, Tong Yi, Zhou Xiangtian, Zhao Fuxin, Yang Li, Zhang Shoukang, Zhang Juanjuan, West Constance E, Guan Min-Xin

Abstract excerpt

PURPOSE: The purpose of this study was to investigate the role of modifier factors in the expression of Leber's hereditary optic neuropathy (LHON). METHODS: Thirty-five subjects from two Han Chinese families with maternally transmitted LHON underwent a clinical and genetic evaluation and molecular analysis of mitochondrial (mt)DNA. RESULTS: Matrilineal relatives in the two Chinese families exhibited a wide range...

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Identifiers

PMID: 20435583
DOI: 10.1167/iovs.09-5027
PMCID: PMC3066600

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