Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families.

doi:10.1167/iovs.09-5027

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families.

Investigative ophthalmology & visual science - 1 Oct 2010

Qu Jia, Wang Ying, Tong Yi, Zhou Xiangtian, Zhao Fuxin, Yang Li, Zhang Shoukang, Zhang Juanjuan, West Constance E, Guan Min-Xin

Abstract excerpt

PURPOSE: The purpose of this study was to investigate the role of modifier factors in the expression of Leber's hereditary optic neuropathy (LHON). METHODS: Thirty-five subjects from two Han Chinese families with maternally transmitted LHON underwent a clinical and genetic evaluation and molecular analysis of mitochondrial (mt)DNA. RESULTS: Matrilineal relatives in the two Chinese families exhibited a wide range...

Topics

Adolescent
Adult
Age of Onset
Animals
Asian People
China
DNA Mutational Analysis
DNA, Mitochondrial
Female
Genetic Predisposition to Disease
Genome, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

NADH Dehydrogenase

Optic Atrophy, Hereditary, Leber

Pedigree

Phylogeny

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 20435583
DOI: 10.1167/iovs.09-5027
PMCID: PMC3066600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20435583-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families.PMID 20435583Read ↗

Only male matrilineal relatives with Leber's hereditary optic neuropathy in a large Chinese family carrying the mitochondrial DNA G11778A mutation.Semantic proximity Read ↗

Very high penetrance and occurrence of Leber's hereditary optic neuropathy in a large Han Chinese pedigree carrying the ND4 G11778A mutation.Semantic proximity Read ↗

Mitochondrial variants may influence the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation.Semantic proximity Read ↗

Leber's hereditary optic neuropathy is associated with the T12338C mutation in mitochondrial ND5 gene in six Han Chinese families.Semantic proximity Read ↗

Leber's hereditary optic neuropathy is associated with the mitochondrial ND6 T14484C mutation in three Chinese families.Semantic proximity Read ↗

Clinical evaluation and mitochondrial DNA sequence analysis in three Chinese families with Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Low penetrance of Leber's hereditary optic neuropathy in ten Han Chinese families carrying the ND6 T11484C mutation.Semantic proximity Read ↗

Frequency and spectrum of mitochondrial ND6 mutations in 1218 Han Chinese subjects with Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Very low penetrance of Leber's hereditary optic neuropathy in five Han Chinese families carrying the ND1 G3460A mutation.Semantic proximity Read ↗

Leber's hereditary optic neuropathy is associated with the mitochondrial ND4 G11696A mutation in five Chinese families.Semantic proximity Read ↗

Leber's hereditary optic neuropathy. New genetic considerations.Semantic proximity Read ↗

Leber's hereditary optic neuropathy is associated with mitochondrial ND1 T3394C mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.