Article

Analysis of Three Primary mtDNA Mutations in 155 Patients with Leber’s Hereditary Optic Neuropathy

2020-11-05

Abstract excerpt

<h4>Background: </h4> Leber’s Hereditary Optic Neuropathy (LHON) is a maternal inherited disease caused by mitochondrial DNA (mtDNA) mutations. The aim of the current study is to analysis the frequencies of mitochondrial ND1 G3460A, ND4 G11778A and ND6 T14484C mutations in patients with LHON. <h4>Methods: </h4>: Our study enrolled 155 patients with LHON and 83 controls, PCR-Sanger sequencing was performed to scree...

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Literature Corpus work: 149be442-04d5-548b-89df-3cadf365d85c
DOI: 10.21203/rs.3.rs-101558/v1

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