Article
The Diagnostic Utility of IDH2 R172 Immunohistochemistry in Tall Cell Carcinoma With Reversed Polarity of the Breast.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000
Sasaki Eiichi, Iwakoshi Akari, Satake Tatsunari, Nakajima Kosei, Kobayashi Mizuho, Ando Yoshiaki, Koshikawa Takashi, Masago Katsuhiro, Honma Naoko, Nishimura Rieko, Kato Yukinari, Ichihara Shu
Abstract excerpt
Tall cell carcinoma with reversed polarity (TCCRP) is a rare histologic type of low-grade breast cancer, consisting of tall columnar cells with reversed nuclear polarity and characterized by frequent IDH2 mutations. We herein report 3 cases of TCCRP with sequencing analyses of the IDH2 gene and immunohistochemical examination using monoclonal antibodies (11C8B1) against IDH2 R172. IDH2 R172 mutations were...
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