Article
Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2020
Pareja Fresia, da Silva Edaise M, Frosina Denise, Geyer Felipe C, Lozada John R, Basili Thais, Da Cruz Paula Arnaud, Zhong Elaine, Derakhshan Fatemeh, D'Alfonso Timothy, Wen Hannah Y, Giri Dilip D, Hayes Malcolm M, Krings Gregor, Bhargava Rohit, Palazzo Juan P, Rakha Emad A, Hoda Syed A, Sanders Melinda E, Collins Laura C, Schnitt Stuart J, Chen Yunn-Yi, Weigelt Britta, Jungbluth Achim A, Reis-Filho Jorge S, Brogi Edi
Abstract excerpt
Tall cell carcinoma with reverse polarity is a rare subtype of breast carcinoma with solid and papillary growth and nuclear features reminiscent of those of the tall cell variant of papillary thyroid carcinoma. These tumors harbor recurrent IDH2 R172 hotspot mutations or TET2 mutations, co-occurring with mutations in PI3K pathway genes. Diagnosis of tall cell carcinomas with reverse polarity is challenging in...
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