Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of the p53‐p16/RB pathway control mechanism in early‐stage carcinogenesis in head and neck squamous cell carcinoma

11 Oct 2022

Abstract excerpt

Head and neck squamous cell carcinoma develops through a heterogeneous process involving human papillomavirus infection, smoking, and alcohol consumption. A comprehensive genomic analysis of head and neck squamous cell carcinomas to date has identified a few single driver gene mutations, the most frequent of which involve TP53 and CDKN2A/p16. To investigate the involvement of the tumorigenesis mechanism in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Head and Neck Cancer Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36218243
DOI: 10.1111/pin.13279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the p53‐p16/RB pathway control mechanism in early‐stage carcinogenesis in head and neck squamous cell carcinomaPMID 36218243Read ↗

Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.Semantic proximity Read ↗

[Mutation signatures in head and neck squamous cell carcinoma : Pathogenesis and therapeutic potential].Semantic proximity Read ↗

Differential transmission of the molecular signature of RBSP3, LIMD1 and CDC25A in basal/ parabasal versus spinous of normal epithelium during head and neck tumorigenesis: A mechanistic study.Semantic proximity Read ↗

Molecular and Cytogenetic Subgroups of Oropharyngeal Squamous Cell CarcinomaSemantic proximity Read ↗

Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctlySemantic proximity Read ↗

Human Papillomavirus Type 16/18 Oncoproteins: Potential Therapeutic Targets in Non-smoking Associated Lung CancerSemantic proximity Read ↗

p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling CascadeSemantic proximity Read ↗

Evidence for at least three alternative mechanisms targeting the p16<sup>INK4A</sup>/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high‐risk human papillomavirusSemantic proximity Read ↗

Active human papillomavirus involvement in Barrett's dysplasia and oesophageal adenocarcinoma is characterized by wild‐type p53 and aberrations of the retinoblastoma protein pathwaySemantic proximity Read ↗

Quantitative methylation analysis reveals gender and age differences in p16<scp>INK</scp>4a hypermethylation in hepatitis B virus‐related hepatocellular carcinomaSemantic proximity Read ↗

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2Semantic proximity Read ↗

HPV16 E7 Protein and hTERT Proteins Defective for Telomere Maintenance Cooperate to Immortalize Human KeratinocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.