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A proteome-scale map of the SARS-CoV-2–human contactome

10 Oct 2022

Abstract excerpt

Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity to efficiently design therapies for emerging virus variants remains an urgent challenge of the ongoing pandemic. Infection and immune reactions are mediated by direct contacts between viral molecules and the host proteome, and the vast majority of these virus-host contacts (the 'contactome') have not been identified. Here, we...

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PMID: 36217029
DOI: 10.1038/s41587-022-01475-z

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