Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis

Abstract excerpt

COVID-19 (Coronavirus disease 2019) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the pathophysiology of this deadly virus is complex and largely unknown, we employ a network biology-fueled approach and integrate multiomics data pertaining to lung epithelial cells-specific co-expression network and human interactome to generate <u>C</u>alu-3-specific human-<...

Topics

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• Bioinformatics and Genomic Networks
• Computational Drug Discovery Methods
• COVID-19 Clinical Research Studies
• Long-Term Effects of COVID-19
• SARS-CoV-2 and COVID-19 Research
• Single-cell and spatial transcriptomics
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

93c82373-2ecf-5d7d-98f1-eeef38dc36c1

DOI

10.2139/ssrn.3581857