Article

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis

2020-04-11

Abstract excerpt

COVID-19 (Coronavirus disease 2019) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the pathophysiology of this deadly virus is complex and largely unknown, we employ a network biology-fueled approach and integrated multiomics data pertaining to lung epithelial cells-specific coexpression network and human interactome to generate C alu-3-specific human- S AR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25d0d825-52a3-52fd-b9cc-9754b8897252
DOI: 10.1101/2020.04.09.033910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 PathogenesisDOI 10.1101/2020.04.09.033910Read

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 PathogenesisSemantic proximity Read

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 PathogenesisSemantic proximity Read

Integrative COVID-19 Biological Network Inference with Probabilistic Core DecompositionSemantic proximity Read

Transcriptome and SARS-CoV-2 biological network directed analysis for better therapeutic developmentSemantic proximity Read

Secondary analysis of transcriptomes of SARS-CoV-2 infection models to characterize COVID-19Semantic proximity Read

Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 PandemicSemantic proximity Read

SARS-CoV-2 meta-interactome suggests disease-specific, autoimmune pathophysiologies and therapeutic targetsSemantic proximity Read

COVID-19: Viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infectionSemantic proximity Read

COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infectionSemantic proximity Read

Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19Semantic proximity Read

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patientsSemantic proximity Read

Molecular signatures in the progression of COVID-19 severitySemantic proximity Read