Article

Structural analysis of SARS-CoV-2 genome and predictions of the human interactome

2020-03-31

Abstract excerpt

<h4>ABSTRACT</h4> Specific elements of viral genomes regulate interactions within host cells. Here, we calculated the secondary structure content of >2000 coronaviruses and computed >100000 human protein interactions with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The genomic regions display different degrees of conservation. SARS-CoV-2 domain encompassing nucleotides 22500 – 23000 is conserved...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d69e6833-8b2a-5764-86e9-ef0ec8e5e184
DOI: 10.1101/2020.03.28.013789

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural analysis of SARS-CoV-2 genome and predictions of the human interactomeDOI 10.1101/2020.03.28.013789Read

Structural analysis of SARS-CoV-2 genome and predictions of the human interactomeSemantic proximity Read

Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infectionSemantic proximity Read

ACE2 Homo-dimerization, Human Genomic variants and Interaction of Host Proteins Explain High Population Specific Differences in Outcomes of COVID19Semantic proximity Read

A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations.Semantic proximity Read

Human Identical Sequences of SARS-CoV-2 Promote Clinical Progression of COVID-19 by Upregulating Hyaluronan via NamiRNA-Enhancer NetworkSemantic proximity Read

Susceptibilities of human ACE2 genetic variants in coronavirus infectionSemantic proximity Read

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesisSemantic proximity Read

SARS-CoV-2 nucleocapsid uniquely disrupts chromatin over pathophysiologically relevant gene promotersSemantic proximity Read

A 3D Structural Interactome to Explore the Impact of Evolutionary Divergence, Population Variation, and Small-molecule Drugs on SARS-CoV-2-Human Protein-Protein InteractionsSemantic proximity Read

SARS-CoV-2 Phylointeractomics Reveal Functional Evolution of Its Variants Across Susceptible Human OrgansSemantic proximity Read

Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans.Semantic proximity Read

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibilitySemantic proximity Read